One and multi-compartments toxico-kinetic modeling to understand metals’ organotropism and fate in Gammarus fossarum

The use of freshwater invertebrates for biomonitoring has been increasing several decades, but little is known about relations between external exposure concentration metals and their biodistribution among different tissues. One multi-compartments toxicokinetic (TK) models are powerful tools to formalize predict how a contaminant bioaccumulated. aim this study develop modeling approaches improve knowledge on dynamic accumulation fate Cd Hg in gammarid’s organs. Gammarids were exposed dissolved (11.1 ± 1.2 µg.L−1 or 0.27 0.13 Hg) before depuration phase. At each sampling days, organs (caeca, cephalon, intestine remaining tissues) separated by dissection analyses. Results allowed us determine that i) G. fossarum takes up as efficiently the mussel M. galloprovincialis, eliminates it more rapidly, ii) which accumulate depurate most, terms concentrations, caeca both metals; iii) one-compartment TK most relevant Hg, while model allows better fit data, demonstrating transfer